Cancer cells grow more rapidly than the cells of most normal tissues, and thus they have greater requirements for nucleotides as precursors to DNA and RNA synthesis. Consequently, cancer cells are generally more sensitive to inhibitors of nucleotide biosynthesis than are normal cells. A growing array of important chemotherapeutic agents act by inhibiting one or more enzymes in these pathways. We will examine several well-studied examples that both illustrate productive approaches to treatment of cancer and facilitate an understanding of how these enzymes work.
Lehninger-Nelson-Cox: Principles of Biochemistry, 730.o.
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