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Many viral oncogenes encode unregulated tyrosine kinase activities, and in some cases the oncogene product is nearly identical to a normal animal-cell receptor, but with the normal signal-binding site defective or missing. For example, the erbB oncogene product, a protein called ErbB, is essentially identical to the normal receptor for epidermal growth factor, except that ErbB lacks the domain that normally binds EGF (Fig. 22-37, p. 777). The erbB2 oncogene is commonly associated with adenocarcinomas (cancers) of the breast, stomach, and ovary.

Lehninger-Nelson-Cox: Principles of Biochemistry, 776.o.